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If you're high up then you'd be visible to quite a few cell sites at once and they really don't like that since you'd be taking up a chunk of spectrum in each cell

I've heard a conspiracy theory that claims this is the true reason you're not allowed to talk on a cell phone on a plane. Seems possible to me the wireless companies would get into the FAA's pocket to conserve bandwidth.

The Mythbusters should see if they can bring down an airliner with a cell phone. I'm sure they couldn't and the mobile phone industry would probably have more to say about the results than the airline industry. How many people shut their wifi off when using laptops on an airplane? I would imagine very few. Planes aren't exactly falling out of the sky.

FWIW, I wouldn't attempt to use my cell phone while flying.